Depression
Conditions
Interventions
cTBS real stimulation group:Random sequences were generated by the researchers on the website https://www.randomizer.org/. A value of =15 was coded as '0' and >15 as '1'. If the value was 0, the parti
cTBS sham stimulation group:Random sequences were generated by the researchers on the website https://www.randomizer.org/. A value of =15 was coded as '0' and >15 as '1'. If the value was 0, the parti
Sponsors
Guangdong Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 30 Years
Inclusion criteria
Inclusion criteria: 1. Healthy adults aged 18-30 2. Right-handed according to the Edinburgh Handedness Inventory 3. No history of neurological diseases, including no brain injury or hand injury 4. Participants voluntarily participate in this study and sign the informed consent form 5. SAS (Self-Rating Anxiety Scale) score < 50 and SDS (Self-Rating Depression Scale) score < 50
Exclusion criteria
Exclusion criteria: 1) There are metal hardware in the body that closely contacts the cTBS stimulation coil (such as cochlear implants, intracranial metal implants, cardiac pacemakers, internal drug pumps, etc.); 2) There are gold or silver electrodes or other metal foreign objects inside the skull; 3) There are electronic components in the body (such as insulin pumps) that are less than 10cm away from the TMS coil; there is a history of neurological or mental disorders such as brain trauma, stroke, epilepsy, schizophrenia, etc.; 4) There is a serious heart disease (such as recent myocardial infarction, arrhythmia) or hypertension that is not effectively controlled; 5) There is a history of epilepsy in the individual or a first-degree relative, or the individual is taking drugs that lower the threshold of epileptic seizures (such as some antidepressants, sedative-hypnotics); 6) There are situations that may lower the threshold of epileptic seizures, such as sleep deprivation, alcohol abuse, drug dependence, etc.; pregnant or lactating women; 7) The individual is unable to cooperate in completing the emotional assessment scale (SAS, PANAS), fNIRS monitoring, behavioral tasks (emotional GO/NO-GO task, probability reward task), or refuses to wear the detection equipment; 8) Patients judged by the researchers to be not suitable for participating in this study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| S-AI Scale Score;PANAS Scale Score;Accuracy of the Emotional GO/NO-GO Task;Reaction time in the emotional GO/NO-GO task;Accuracy of probabilistic reward tasks;Reaction time for probabilistic reward tasks; | — |
Countries
China
Contacts
Public ContactXu Guangqin
Guangdong Provincial People's Hospital
Outcome results
None listed