Exploring the Physiological Mechanisms of Health Volunteers
Conditions
Interventions
Healthy participants:Interventions were performed once in the morning, at noon, and in the evening, using intermittent theta burst stimulation (iTBS) targeting the left motor cortex M1, at an intensit
Sponsors
Huashan Hospital Affiliated to Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: 1. Age 18–35 years old, right-handed; 2.Physically and mentally healthy, with no history of neurological disorders, mental health disorders, or sleep disorders; 3. No organic diseases outside the indications for transcranial magnetic stimulation (e.g., no intracranial implants or other conditions that could affect TMS safety).
Exclusion criteria
Exclusion criteria: 1. A history of long-term use of medications that may affect circadian rhythms (such as melatonin, sleeping pills, antidepressants, etc.); 2. Irregular daily routines in the past month, such as night shift or rotating shift work, travel across two or more time zones, persistent staying up late, or sleep deprivation; 3. Daily caffeine intake exceeding 300 mg (approximately equivalent to two medium cups of coffee); 4.Other situations deemed inappropriate for participation in this study by the researchers (for example, inability to cooperate with multiple experiments).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in TMS-evoked potentials (TEP) of left M1; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in EEG functional connectivity (ERSP, PLV);Changes in Spatiotemporal Occlusion Task performance; | — |
Countries
China
Contacts
Public ContactYulian Zhu
Huashan Hospital Affiliated to Fudan University
Outcome results
None listed