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Dynamic Changes in Early Post-Extubation Diaphragmatic Ultrasound in ICU Patients on Mechanical Ventilation and Their Correlation with Grip Strength and Adverse Respiratory Outcomes: A Prospective Obs

Dynamic Changes in Early Post-Extubation Diaphragmatic Ultrasound in ICU Patients on Mechanical Ventilation and Their Correlation with Grip Strength and Adverse Respiratory Outcomes: A Prospective Observational Study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500113207
Enrollment
Unknown
Registered
2025-11-26
Start date
2025-12-01
Completion date
Unknown
Last updated
2025-12-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diaphragmatic atrophy

Interventions

Observation group:None

Sponsors

Shanghai General Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1.Undergo tracheal intubation or tracheotomy; 2.Patients requiring mechanical ventilation for >=48 hours; 3.Adult patients scheduled for an initial assessment within 24 hours of extubation;

Exclusion criteria

Exclusion criteria: 1.History of neuromuscular disease; 2.Severe obesity (defined as a body mass index [BMI] greater than 35); 3.Conditions that may interfere with diaphragmatic ultrasound examinations, such as thoracic trauma, recent thoracic surgery, or severe pneumothorax; 4.Pregnancy; 5.The clinical prognosis is deemed insignificant, and the decision to forgo life-sustaining treatment is documented;

Design outcomes

Primary

MeasureTime frame
Grip strength;—

Secondary

MeasureTime frame
Dynamic changes in grip strength;Incidence of persistent diaphragmatic atrophy;Adverse respiratory outcomes (reintubation rate, incidence of pneumonia, duration of mechanical ventilation, ICU length of stay);Dynamic parameters of diaphragmatic function (diaphragmatic mobility, inspiratory time, end-inspiratory thickness, end-expiratory thickness, thickening fraction, mean contraction velocity);—

Countries

China

Contacts

Public ContactLan Chen

Shanghai General Hospital

13636317690@126.com+86 18001890326

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026