Malignant biliary obstruction
Conditions
Interventions
experimental group:Biliary stent implantation combined with 12?I seed brachytherapy
Control group:Treatment with an ordinary biliary stent
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: (1) Aged between 18 and 90 years; (2) Clinically or pathologically confirmed malignant biliary obstruction; (3) Presence of symptoms related to malignant biliary obstruction (jaundice, pruritus, cholangitis, or pain); (4) Bismuth-Corlett type ?, ?, ?, or ? obstruction diagnosed by MRCP and/or contrast-enhanced CT; (5) Unresectable obstruction due to diffuse lesions, metastasis, poor clinical baseline conditions of the patient, or refusal of surgical resection; (6) Conscious and cooperative.
Exclusion criteria
Exclusion criteria: (1) Patients with benign biliary stricture; (2) Patients with biliary stricture that cannot be dilated sufficiently to allow passage of the delivery system; (3) Perforation of any duct within the biliary tree; (4) Presence of a metallic biliary stent or history of biliary surgery; (5) Contraindications to percutaneous transhepatic cholangiography (PTC) procedure; (6) Active hepatitis; (7) Extensive intrahepatic metastasis involving both liver lobes; (8) Uncooperative or inability to provide authorization and signature.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Technical success;Jaundice relief;Surgery-related complications; | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall survival(OS);Safety; | — |
Countries
China
Contacts
Public ContactHong Wu
West China Hospital of Sichuan University
Outcome results
None listed