Gastro-oesophageal reflux disease
Conditions
Interventions
Observation group (anti-reflux mucoplasty):None
Sponsors
Changzhou Second People' s Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.History of at least 6 months of double-dose PPIs or P-CAB therapy with persistent typical reflux symptoms occurring at least twice weekly; 2. Diagnosis of GERD confirmed by clinical symptoms, gastroscopy, and radiographic examination; 3.Hiatal hernia<=3 cm; 4.Age between 18 and 75 years.
Exclusion criteria
Exclusion criteria: 1.Pregnancy, lactation, severe obesity, or major psychiatric illness; 2.Achalasia or EGJ outflow obstruction;3.Severe cardiac, hepatic, or renal dysfunction; 4.Previous esophageal or gastric surgery;5.Eosinophilic esophagitis.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Hill’s flap grade;Los Angeles classification;Incidence of adverse events; | — |
Primary
| Measure | Time frame |
|---|---|
| GERD-HRQL;Proportion of patients capable of discontinuing PPI; | — |
Countries
China
Contacts
Public ContactLin Min
Changzhou Second People' s Hospital of Nanjing Medical University
Outcome results
None listed