endometriosis
Conditions
Interventions
Case group:NA
Normal control group:None
Sponsors
The Third Xiangya Hospital of Central South University
Eligibility
Sex/Gender
Female
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1.Case Group: (1) Females of reproductive age (18-50 years) with regular menstrual cycles in the preceding 3 months; (2) No hormone therapy within the preceding 3 months; (3) No intrauterine device in place; (4) Intraoperative or postoperative pathological diagnosis of endometriosis (EMS), including ovarian endometrioma, peritoneal endometriosis, deep infiltrating endometriosis (DIE), or adenomyosis; (5) Signed informed consent. 2.Normal Control Group: (1) Females of reproductive age (18-50 years) with regular menstrual cycles in the preceding 3 months; (2) No hormone therapy within the preceding 3 months; (3) No clinical or imaging evidence of endometriosis preoperatively; patients presented with other gynecological conditions, and no endometriotic lesions were identified intraoperatively. (4) Signed informed consent.
Exclusion criteria
Exclusion criteria: 1. The exclusion criteria for both the case group and control group are identical: (1) Having undergone relevant hormone therapy within the past three months; (2) Concurrent malignant tumours and/or severe internal or surgical conditions; (3) Concurrent significant gynaecological conditions such as endometrial polyps, submucosal uterine fibroids, or pelvic inflammatory disease; (4) Inability to obtain sufficient tissue samples intraoperatively, or autolysis of tissue samples, or missing paraffin blocks; Refusal to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Relative expression fold difference between lesion vs in situ endometrium vs normal endometrium group >=1.5-fold and P < 0.05;The median H-score of lesions was more than 3 points higher than that of controls, with P < 0.05.;PTX3 concentration; | — |
Countries
China
Contacts
Public ContactFei Zeng
The Third Xiangya Hospital of Central South University
Outcome results
None listed