Breast Cancer
Conditions
Interventions
The Arimidex group:Aripiprazole group: Before the induction of anesthesia during the surgery, 130mg of aripiprazole injection (microemulsion) was intravenously administered. 18mL (130mg dose) of aripi
Control group:Control group: 18 ml of normal saline was intravenously injected 2 minutes before the induction of anesthesia, and 4 mg of ondansetron was intravenously injected at the end of the surger
Sponsors
Shanxi Provincial Cancer Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients scheduled for elective breast cancer surgery under general anesthesia with an operation time of no more than 3 hours; 2. Patients aged 18 to 65 years, weighing 48 to 80 kg, with no restrictions on race; 3. American Society of Anesthesiologists (ASA) physical status classification I to II; 4. Agree to participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Those who refuse to participate in this study; 2. Those who are allergic to the active ingredients of aprepitant and ondansetron or any of the excipients; 3. Those who have taken pimozide; 4. Those who have received anti-nausea and anti-vomiting drugs, steroid drugs or any other drugs known to cause nausea and vomiting within 72 hours before the surgery; 5. Those who have obvious organic functional abnormalities in the heart, lungs, liver, kidneys, etc. before the surgery; 6. Those who have severe neurological or mental abnormalities before the surgery; 7. Those with a BMI greater than 30 or less than 18 kg/m^2; 8. Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complete response rate (CR); | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence rate of nausea and vomiting;PACU stay time;The severity of nausea;The usage situation of antiemetic rescue drugs;Patient satisfaction.; | — |
Countries
China
Contacts
Public ContactTian Shouyuan
Shanxi Provincial Cancer Hospital
Outcome results
None listed