gynecological disease
Conditions
Interventions
Chlorhexidine group:Use chlorhexidine mouthwash before the operation to rinse the mouth
Control group:Rinse mouth with saline solution
Sponsors
Peking University Third Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Elective gynecological laparoscopic surgery under general anesthesia with an expected operation time of more than 2 hours; 2. Female patients aged 18 years or older; 3. American Society of Anesthesiologists (ASA) classification I-III; 4. BMI 18-30 kg/m^2; 5. No obvious dental caries, periodontitis, oral abscess, precancerous lesions, fungal infections, or pericoronitis of wisdom teeth in the entire mouth.
Exclusion criteria
Exclusion criteria: 1. The patient refused to participate in the study; 2. Within the past 6 months, the patient has used antibiotics or immunosuppressants systemically; 3. Within the past 6 months, the patient has a history of oral medication and surgical treatment; 4. Has been using sedatives or glucocorticoids for a long time; 5. Pregnant or lactating women; Women or men with reproductive capacity who are unwilling to use contraception throughout the study period; Or subjects who have a pregnancy plan within 3 months after the study ends; 6. Those with cognitive dysfunction or inability to communicate; 7. Allergic to chlorhexidine mouthwash; 8. With a history of alcohol or drug dependence or abuse; 9. Difficult to follow up or have poor compliance; 10. The investigator considers that there are any other factors that make the subject unsuitable to participate in this clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oral microbiota; | — |
Countries
China
Contacts
Public ContactLi Zhengqian
Peking University Third Hospital
Outcome results
None listed