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Experimental study and clinical application of pulp decompression membrane combined with bioactive materials in the preservation of vital pulp in infected teeth

Experimental study and clinical application of pulp decompression membrane combined with bioactive materials in the preservation of vital pulp in infected teeth

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500113169
Enrollment
Unknown
Registered
2025-11-25
Start date
2024-09-01
Completion date
Unknown
Last updated
2026-05-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Irreversible pulpitis

Interventions

Decompression membrane group:Decompression membrane decompression restoration and pulp regeneration therapy

Sponsors

Affiliated Hospital of Stomatology, Nanjing Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: For the initial stages of irreversible pulpitis caused by deep caries or other factors such as increased pulpal pressure, in which the tooth has completed development, as an alternative treatment to vital pulpotomy. Those who fulfill the following conditions: 1. Patients with irreversible pulpitis, that is, those who exhibit clinical symptoms of irreversible pulpitis: a history of cold and/or heat-stimulated pain (induced pain lasting more than 30 s), a history of spontaneous, nocturnal, and radiating pain, and a history of pain affected by change in body position may be present. Clinical examination of cold stimulus sensitivity or excitation pain, discomfort, or pain on percussion. 2. X-ray examination shows complete root development, a low-density image of the crown near the pulp, and no obvious low-density image of the apical pulp. There may be a periodontal membrane widening image. 3. In the course of treatment, there was bleeding in the pulp after removing the caries, and no liquefaction necrosis of the pulp occurred under the microscope, and the active bleeding was controlled by rinsing the pulp with NaClO and physiological saline alternately for 5-10 min.

Exclusion criteria

Exclusion criteria: 1. The affected tooth exhibits symptoms such as "heat pain relieved by cold" or even no response to cold stimulation (indicating abscessed and necrotic dental pulp). 2. In cases where the affected tooth has cracks that extend beyond the marginal ridge or other conditions requiring crown restoration. 3. The patient has moderate to severe periodontitis, or the affected tooth has combined periodontal and pulpal pathology. 4. The tooth has periapical lesions or internal or external root resorption. 5. The pulp is obviously liquefied and necrotic under the microscope after removing the decay, and the bleeding from the pulp wound is difficult to control. 6. The patient is unable to return to the clinic on time.

Design outcomes

Primary

MeasureTime frame
Imaging indicators;Pain indicators;Pulp vitality;

Countries

China

Contacts

Public ContactWei Xin

Affiliated Hospital of Stomatology, Nanjing Medical University

weixinart@163.com+86 178 4990 8294

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 7, 2026