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Effect of esketamine on postoperative opioid consumption in patients undergoing lower extremity joint replacement surgery in the context of multimodal analgesia: a retrospective cohort study

Effect of esketamine on postoperative opioid consumption in patients undergoing lower extremity joint replacement surgery in the context of multimodal analgesia: a retrospective cohort study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500113149
Enrollment
Unknown
Registered
2025-11-25
Start date
2025-12-01
Completion date
Unknown
Last updated
2025-12-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lower Limb Arthroplasty

Interventions

Non-exposed group (no esketamine group):none

Sponsors

The Affiliated Hospital of Qingdao University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: The included data are all derived from original clinical studies that have passed ethical review, and their data collection procedures comply with relevant ethical norms and requirements. All research subjects corresponding to the included data have met the predetermined inclusion criteria of the original studies, signed the informed consent, and been verified as qualified samples through quality checks in the original studies. The original data are completely recorded with standardized formats, without missing key information that would affect the preset analysis of this study and can be directly extracted for statistical analysis.

Exclusion criteria

Exclusion criteria: This study is a secondary analysis of clinical data, and all data are derived from original clinical studies that have passed ethical review. The original studies have established strict inclusion and exclusion criteria and completed the screening of eligible samples. This study conducts analysis based on the eligible samples from the original studies, with no additional data exclusion, and all original eligible samples are included in the analysis.

Design outcomes

Primary

MeasureTime frame
Postoperative opioid consumption;

Secondary

MeasureTime frame
Postoperative Phased Opioid Consumption;Pain levels at rest and exercise after surgery;Time to First Press of the Postoperative Patient-Controlled Analgesia (PCA) Pump;Postoperative Timed Up and Go Test;Postoperative Active Range of Motion;Time to discharge criteria after surgery;Postoperative Length of Hospital Stay;

Countries

China

Contacts

Public ContactYouzhuang Zhu

The Affiliated Hospital of Qingdao University

youzhuang_zhu@qdu.edu.cn+86 532 8291 9395

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026