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Comparison of the Effects of Biosimilar QL1205 and Lucentis® on OCTA and Aqueous Humor Biomarkers in Patients with Macular Edema due to Retinal Vein Occlusion

Compare the effects of the biosimilar QL1205 and Lucentis® on OCTA and aqueous humor biomarkers in patients with macular edema due to retinal vein occlusion

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500113142
Enrollment
Unknown
Registered
2025-11-25
Start date
2025-12-15
Completion date
Unknown
Last updated
2025-12-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Macular edema due to retinal vein occlusion

Interventions

QL1205 group :Domestic Ranibizumab Injection
Lucentis group:Lucentis (Ranibizumab Injection, Imported)

Sponsors

Bengbu Municipal Second People Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Patients who are diagnosed with macular edema due to retinal vein occlusion at our hospital and have not received prior treatment; 2. Both the patients and their family members have given informed consent and are able to complete a one - year follow - up.

Exclusion criteria

Exclusion criteria: 1. Patients with a history of fundus diseases or those who have previously undergone ophthalmic surgical treatment; 2. Patients who are systemically or ocularly unfit for fluorescein fundus angiography (FFA) and intravitreal injection of VEGF inhibitors; 3. Patients with severe abnormalities in vital organs such as the cardiovascular system, liver, and kidneys, and are unable to tolerate ophthalmic examinations and treatments; 4. Poor - quality OCT or OCTA images.

Design outcomes

Primary

MeasureTime frame
Vision;

Secondary

MeasureTime frame
Optical coherence tomography angiography result ;Aqueous humor biomarker ;

Countries

China

Contacts

Public ContactHaiyue Yu

Bengbu Municipal Second People Hospital

569476927@qq.com+86 136 6507 1937

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026