Atherosclerosis
Conditions
Interventions
Lower extremity atherosclerotic occlusive disease group:None
Coronary artery disease group:None
Control group:None
Sponsors
Peking Union Medical College Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with lower extremity atherosclerotic occlusive disease must have atherosclerotic lower extremity ischemic symptoms classified as >= Rutherford Class II, an ABI 50%. 2. Control group: Age- and sex-matched individuals without symptoms or signs of lower extremity ischemic claudication and with an ABI > 0.9.
Exclusion criteria
Exclusion criteria: 1. Use of antibiotics or corticosteroids within the past 6 months. 2. Use of probiotics within the past 6 months. 3. History of gastrointestinal diseases (e.g., inflammatory bowel disease). 4. History of abdominal surgery (e.g., gastrectomy). 5. Major dietary changes within 1 week prior to sample collection. 6. Ongoing infectious disease, cancer, or renal or hepatic failure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fecal flora;Fecal microbiota metagenomics;Serum metabolomics;Fecal metabolomics; | — |
Secondary
| Measure | Time frame |
|---|---|
| Biochemical indicators;Develop diagnostic and prognostic models for the disease.; | — |
Countries
China
Contacts
Public ContactLiu Bao
Peking Union Medical College Hospital
Outcome results
None listed