Pain
Conditions
Interventions
Control group:Sufentanil
Sponsors
Shenzhen People's Hospital
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. The patient is aged 60 years or above; gender is not restricted. 2. ASA II-III grade. 3. Able to understand the VAS score. 4. Body Mass Index (BMI) is between 18 and 30 kg/m^2 (including the boundary values). 5. Vital signs during the screening period: respiratory rate >= 10 and = 95% when breathing air; systolic blood pressure (SBP) >= 90 mmHg and = 60 mmHg and =55 and <=100 beats per minute. 6. Understands the procedures and methods of this study, is willing to sign the informed consent form and strictly follow the trial protocol to complete this study.
Exclusion criteria
Exclusion criteria: 1. The patient is unconscious and has limited self-awareness; 2. Combined local anesthesia; 3. Conversion to open surgery; 4. It is expected that there will be difficulties in intubation or ventilation (modified Mallory score is level III or IV); 5. Before or during screening, any of the following respiratory management risks exist: 1) History of asthma; 2) Patients with sleep apnea syndrome; 3) COPD; 6. Chronic pain (for three months) or chronic use of analgesics (for three months); 7. Current or past drug addiction; 8. Participants who have participated in any drug clinical trials within the previous 1 month; 9. Use of drugs that may affect the QT interval within 2 weeks before or during screening; 10. Laboratory test indicators for the selection period meet the following standards: (1) AST and ALT >= 3×ULN; (2) TBIL >= 1.5×ULN;( 3) Hb = 1.5×ULN; 11.The investigators consider any participants with any other factors that are not suitable for participating in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain Visual Analogue Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse reactions of opioids; | — |
Countries
China
Contacts
Public ContactLiu Xicheng
Shenzhen People's Hospital
Outcome results
None listed