Aging
Conditions
Interventions
Healthy Control Group:None
Sponsors
Nanjing Drum Tower Hospital
Eligibility
Sex/Gender
All
Age
35 Years to 75 Years
Inclusion criteria
Inclusion criteria: Healthy Control Group 1. Age 35-75 years. 2. In good general health with no history of major surgery under general anesthesia, and no history or current diagnosis of the following major diseases or significant chronic conditions, including: a. Malignant tumors (excluding polycythemia vera, basal cell or squamous cell skin cancer); b. Coronary artery disease/myocardial ischemic disease/heart failure; c. Stroke/cerebral infarction/transient ischemic attack; d. Alzheimer's disease/Parkinson's disease; e. Deep vein thrombosis/pulmonary embolism; f. Chronic kidney disease/hemodialysis treatment/history of severe renal impairment; g. Autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, Crohn's disease, etc.; h. Aortic aneurysm or cerebral aneurysm; i. Diabetes (glycated hemoglobin >6.5% or fasting blood glucose >126 mg/dL, or currently taking diabetes medication or insulin therapy); j. Recent cardiovascular events (myocardial infarction, coronary intervention, coronary artery bypass grafting); k. Infectious diseases such as HIV, hepatitis, tuberculosis, etc.; l. Hand or lower limb disability affecting normal function and daily life. 3. Voluntarily signed informed consent form. Surgical Group 1. Age 55-65 years. 2. Scheduled for elective lumbar spine surgery under general anesthesia (anticipated duration >=2 hours). 3. American Society of Anesthesiologists (ASA) physical status classification I-III. 4. Other criteria correspond to points 2) and 3) of the inclusion criteria for the healthy volunteer group.
Exclusion criteria
Exclusion criteria: Healthy Control Group 1. Scheduled to undergo surgery under general anesthesia during the research follow-up period. 2. Refusal to participate or inability to cooperate with follow-up. 3. Women who are pregnant, lactating, or diagnosed with premature ovarian insufficiency, hysterectomy, or endometrial ablation. 4. Current use of any of the following medications: a. Chemotherapeutic agents (e.g., tamoxifen, doxorubicin, etc.); b. Antiplatelet agents (e.g., clopidogrel/Plavix, dipyridamole/Aggrenox, ticlopidine/Ticlid, excluding aspirin); c. Cholinesterase inhibitors (e.g., donepezil/Aricept). 5. Treatment with any investigational drug or device within 30 days prior to enrollment, or participation in any other clinical trial within 3 months prior to enrollment, or vaccination within 2 weeks prior to enrollment. Surgical Group 1. History of other major surgery under general anesthesia within the past 12 months. 2. Preoperative frailty score (FRAIL Scale) >= 3 points. 3. Presence of severe sensory impairment affecting follow-up assessments. 4. Other criteria correspond to points 2 to 5 of the exclusion criteria for the Healthy Control Group.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| biological age; | — |
Secondary
| Measure | Time frame |
|---|---|
| Accelerated Aging Clock;Postoperative Complications;General Statistical Data;complication;Cognitive Assessment;Sleep Assessment;Frailty Assessment;Anxiety Assessment;Depression Assessment;Pain Assessment;Activities of Daily Living (ADL) Assessment;Complete Blood Count (CBC);Glycated Hemoglobin (HbA1c);Comprehensive Metabolic Panel (CMP);Sex Hormone Panel;Urinalysis;Stool Routine Examination;Bone Mineral Density (BMD);Electroencephalography (EEG);Electrocardiography (ECG / EKG);Whole-Body Adipose Tissue Distribution Assessment;Aging Biomarkers;Anesthesia Information;Intraoperative Adverse Events;Readmission/Death; | — |
Countries
China
Contacts
Public ContactXiaoping Gu
Affiliated Drum Tower Hospital, Medical School of Nanjing University
Outcome results
None listed