Gynecological diseases
Conditions
Interventions
Remimazolam group:During the maintenance phase of anesthesia, remimazolam was continuously pumped intravenously (0.2-1mg/kg/h), and reasonable adjustment was made according to cerebral perfusion index
Propofol group:Propofol (4-12mg/kg/h) was continuously pumped intravenously during the maintenance phase of anesthesia, and reasonable adjustment was made according to cerebral perfusion indexes and h
Sponsors
Yi Jishan Hospital,the First Affiliated Hospital of Wannan Medical College
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) Age: over 18 years old, under 65 years old; 2) ASA I-II patients undergoing laparoscopic gynecological surgery; 3) the operation time is more than 1 hour and less than 3 hours; 4) Signed informed consent: All participants signed formal informed consent.
Exclusion criteria
Exclusion criteria: 1) subjects with ocular diseases such as glaucoma or intracranial lesions; 2) long-term use of sedatives/analgesics; 3) participants participated in other clinical research within 3 months before screening; 4) The subjects had liver and kidney dysfunction or severe cardiopulmonary, vascular, or nervous system diseases. 5) During the operation, the operation method was temporarily changed to open surgery or unexpected circumstances occurred that affected the study process.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Optic nerve sheath diameter;Time-averaged mean flow velocity in the middle cerebral artery;Peak systolic velocity of the middle cerebral artery;Middle cerebral artery end-diastolic flow velocity;Time-average maximum velocity of middle cerebral artery;Middle cerebral artery blood flow;Ratio of middle cerebral artery systolic to diastolic velocity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure;Heart rate;Total intraoperative doses of propofol and remimazolam;Scores for postoperative pain, nausea and vomiting, as well as the usage of additional antiemetic drugs and analgesic drugs;Postoperative recovery quality score (QoR-15);Incidence of Postoperative complications;Postoperative recovery time (extubation time, orientation recovery time); | — |
Countries
China
Contacts
Public ContactYongquan Chen;Taotao Liu
Yiji Mountain Hospital, the First Affiliated Hospital of Wannan Medical College
Outcome results
None listed