Respiratory failure
Conditions
Interventions
Sedation and analgesia Observation Group:None
Sponsors
The First Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: ICU patients aged between 18 and 70 with sepsis who have received invasive mechanical ventilation for more than 24 hours and need continuous use of remifentanil or hydromorphinone analgesic drugs.
Exclusion criteria
Exclusion criteria: 1.Patients who need to use a ventilator for a long time after tracheotomy; 2. Severe central nervous system diseases (acute stroke, uncontrolled epilepsy, severe dementia); Liver diseases (Child-Pugh grades B and C); Acute myocardial infarction Degree II/III atrioventricular block Heart rate is lower than 50 beats per minute; Patients with hemodynamic instability; Patients who need deep sedation in clinical practice; Severe ARDS (PaO2/FiO2=5cmH2O); 3. Those who are dependent on benzodiazepines or opioids; Drug abuse and alcoholism; 4. Has participated in other research;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ICU Length of Stay;Duration of Mechanical Ventilation; | — |
Secondary
| Measure | Time frame |
|---|---|
| CPOT Score;Constipation;Vital Signs;Outcome; | — |
Countries
China
Contacts
Public ContactDing Chengzhi
The First Affiliated Hospital of Nanchang University
Outcome results
None listed