Metabolic and Cardiovascular disease
Conditions
Interventions
Mediterranean diet group:Subjects are given a Mediterranean diet
High protein diet group:Subjects are given a High protein diet
Sponsors
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
16 Years to 30 Years
Inclusion criteria
Inclusion criteria: 1. Body mass index (BMI) between 16 and 28 kg/m^2; 2. Age between 16 and 30 years; 3. No other metabolic diseases (e.g., diabetes, hypertension); 4. No recent history of surgery, trauma, or major illnesses; 5. No long-term use of medications that affect energy metabolism, such as hormonal agents, weight-loss drugs, or hypoglycemic medications.
Exclusion criteria
Exclusion criteria: 1. Physical limitations (e.g., musculoskeletal injuries, joint diseases, or pain); 2. Known severe cardiovascular, cerebrovascular, hepatic, or renal diseases; 3. Exercise-induced dyspnea; 4. Known family history of sudden cardiac death; 5. Diagnosed coronary artery disease; 6. Untreated endocrine disorders; 7. Blood pressure >=160/100 mmHg; 8. Use of medications affecting metabolism or cardiovascular function within the past year; 9. Smoking or weekly alcohol consumption >140 g (men) or >70 g (women); 10. Inability to adhere to the training protocol during the study period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Body composition (Body weight, fat mass, fat-free mass);Energy metabolism (Total daily energy expenditure, carbohydrate and fat oxidation, thermic effect of food);gut microbiota; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in blood biochemical markers: blood glucose, blood lipids, lactate, hormones, and other indicators;Changes in physiological parameters: heart rate, blood pressure, blood oxygen saturation, heart rate variability, etc.;Subjective questionnaires;Sleep quality; | — |
Countries
China
Contacts
Public ContactGuang Ning
Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Outcome results
None listed