Alzheimers disease
Conditions
Interventions
Sham group:The sham stimulation group received identical parameter settings as the rTMS group, but used a dedicated sham coil that does not generate an effective magnetic field in the cortex.
DLPFC-rTMS:Received 14 consecutive days of rTMS intervention, with stimulation intensity set at 90% of resting motor threshold, frequency of 20 Hz, 2 s per train, 28 s inter-train interval, 40 trains
DLPFC-iTBS:iTBS stimulation was applied to the left dorsolateral prefrontal cortex. The stimulation intensity was set at 70% of the resting motor threshold, using a burst pattern with three pulses per
a total of 600 pulses were delivered per session, lasting 190 s. Three sessions were performed daily, with 15-minute intervals between each session.
Sponsors
Tianjin Huanhu Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 85 Years
Inclusion criteria
Inclusion criteria: Recruitment criteria for AD subjects are: 1. Age 50–85 years, meeting NIA-AA diagnostic criteria for Alzheimer’s disease (AD); 2. Mini-Mental State Examination (MMSE) score between 10 and 27; 3. Mild to moderate AD, defined by Clinical Dementia Rating (CDR) <= 2; 4. Patients and their families possess legal capacity to understand the study and provide informed consent. All diagnoses and enrollments were determined by senior neurologists.
Exclusion criteria
Exclusion criteria: Exclusion criteria for AD subjects were: 1. History of epilepsy or other neurological disorders; 2. Severe depression with Hamilton Depression Scale (HAMD) score >20; 3. Presence of visual or auditory impairments; 4. History of any severe chronic systemic disease, brain injury, or alcohol/substance abuse; 5. Presence of any contraindications to TMS.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mini-Mental State Examination;Montreal Cognitive Assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Electroencephalography (EEG);Magnetic Resonance Imaging (MRI);Blood biomarker;Other scales: Activities of Daily Living (ADL) Scale, Hamilton Depression Rating Scale (HAMD/HDRS), Auditory Verbal Learning Test (AVLT), Digit Span Test (DST), Boston Naming Test (BNT), Verbal Fluency Test (VFT), Stroop Color-Word Test (SCWT), and Trail Making Test (TMT).; | — |
Countries
China
Contacts
Public ContactYin Shaoya
Tianjin Huanhu Hospital
Outcome results
None listed