Postpartum Blues
Conditions
Interventions
Experimental: Esketamine Group:After umbilical cord clamping, the investigational drug was initiated via intravenous infusion. The agent was diluted in 20 mL of normal saline and administered at a rat
Placebo Control: Normal Saline Group:After umbilical cord clamping, an equivalent volume of normal saline was infused at the same infusion rate and for the same duration as in the experimental group.
Sponsors
Huzhou Maternity & Child Health Care Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Age between 18 and 45 years; 2.Full-term pregnancy; 3.Pre-pregnancy body mass index (BMI) of 18.5–40 kg/m^2; 4.Medically healthy with stable cardiovascular vital signs; 5.American Society of Anesthesiologists (ASA) physical status I–III; 6.Scheduled for elective cesarean section at Huzhou Maternity & Child Health Care Hospital; 7.Capable of understanding study procedures and assessment instruments, and able to communicate effectively with research personnel; 8. Provides voluntary informed consent to participate in the study.
Exclusion criteria
Exclusion criteria: 1.History of mental illness ( such as depression, schizophrenia, etc. ) or communication disorders; 2.Serious pregnancy complications ( such as severe preeclampsia, placenta implantation, HELLP syndrome, placenta previa, placental abruption, etc. ); 3.Contraindications to S-ketamine ( such as refractory or refractory hypertension, severe cardiovascular disease [ cardiac function grade = grade III ], hyperthyroidism, etc. ); 4.Current use of medications that influence mood or treat conditions associated with mood instability; 5.Disorders of reproductive hormone metabolism or recent hormonal therapy; 6.Presence of significant preoperative depression risk factors (e.g., prolonged exposure to domestic violence, recent bereavement); 7.Those who refused to participate in the experiment.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Profile of Mood States (POMS);Stein Maternity Blues Scale Score;Postpartum Depression;Postoperative Pain;Postoperative Sleep Quality; | — |
Primary
| Measure | Time frame |
|---|---|
| Change in depressive mood, representing the severity of PPB; | — |
Countries
China
Contacts
Public ContactQin Cheng
Huzhou Maternity & Child Health Care Hospital
Outcome results
None listed