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Dietary Polysaccharides Alleviate Atherosclerosis via Akkermansia muciniphila-Mediated Restoration of the Mucus Barrier

Dietary Polysaccharides Alleviate Atherosclerosis via Akkermansia muciniphila-Mediated Restoration of the Mucus Barrier

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500113062
Enrollment
Unknown
Registered
2025-11-24
Start date
2025-12-01
Completion date
Unknown
Last updated
2025-12-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atherosclerosis

Interventions

Disease group:None
Health group:None

Sponsors

Zhejiang Provincial People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1. Confirmation of >=50% stenosis in the coronary arteries by coronary CT angiography (CTA) or digital subtraction angiography (DSA); 2. 18 years of age or older; 3. Patient voluntarily agrees to participate in the study and signs the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Use of antibiotics or undergoing fecal microbiota transplantation within the past month; 2. Use of probiotic supplements within the past month; 3. Severe systemic diseases, such as advanced malignant tumors, active infections, or end-stage liver and kidney dysfunction; 4. Long-term use of systemic glucocorticoids or immunosuppressants.

Design outcomes

Primary

MeasureTime frame
Metagenomic analysis;Metabolomics analysis;

Countries

China

Contacts

Public ContactMiaoyu Li

Zhejiang Provincial People's Hospital

limiaoyu66@163.com+86 188 5117 6707

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026