Opioid-related adverse reactions
Conditions
Interventions
Sufentanil + Nalmefene group:Intravenous patient-controlled analgesia (PCA) postoperatively includes sufentanil at a dose of 1.5–2.5 µg/kg plus naloxone at a continuous infusion rate of 0.06 µg/kg/h,
Sufentanil + Butorphanol group:Intravenous patient-controlled analgesia (PCA) postoperatively includes sufentanil at a dose of 1.5–2.5 µg/kg plus butorphanol at a dose of 30–40 µg/kg, with all other p
Sufentanil group:Intravenous patient-controlled analgesia (PCA) postoperatively includes sufentanil at a dose of 1.5–2.5 µg/kg, diluted with normal saline to a total volume of 100 mL, with a backgroun
Sponsors
Wenzhou Medical University Affiliated Second Hospital, Wenzhou Medical University Affiliated Yuying Children's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Voluntarily participate in this experiment and sign the informed consent form. 2. American Society of Anesthesiologists (ASA) physical condition classification I-III level. 3. Patients aged 18 years or older undergoing spinal surgery.
Exclusion criteria
Exclusion criteria: 1. Patients still on tracheal intubation after surgery; 2. Patients with difficulty in verbal communication; 3. Patients with severe liver or kidney diseases; 4. Patients taking psychotropic drugs; 5. Patients with a history of allergic reaction to the studied drug.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of opioid-related adverse reactions, such as postoperative nausea and vomiting, and abdominal distension.;Time to first ambulation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual Analog Scale (VAS) scores for pain at rest and during movement at various time points within 48 hours postoperatively.;Time to first water intake;Time to first liquid diet;Time to start passive in-bed exercise;Length of postoperative hospital stay;Patient satisfaction;Time to first anal exhaust;Total intraoperative and PACU analgesic consumption, and rescue analgesic use in the ward.;Time to resumption of normal diet postoperatively.; | — |
Countries
China
Contacts
Public ContactLi Jun
Wenzhou Medical University Affiliated Second Hospital, Wenzhou Medical University Affiliated Yuying Children's Hospital
Outcome results
None listed