Acute graft versus host disease
Conditions
Interventions
Case group:None
Control group:None
Sponsors
The Second Affiliated Hospital of the Army Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. From September 2025 to September 2027, patients aged 18-50 years old who were diagnosed with GI-aGVHD after allogeneic hematopoietic stem cell transplantation were selected as the case group, and patients without GI-aGVHD after allogeneic hematopoietic stem cell transplantation were selected as the control group. 2. Voluntarily participate in this study and sign informed consent; 3. Wthout serious damage of vital organs: (1) creatinine =2g/dl; (3) cardiac ejection index >50%; (4) heme >9g/dL, bilirubin < 2.0mg/dl; 4. Blood routine, liver and kidney function, coagulation routine were normal; 5. There were no other contraindications to intestinal biopsy.
Exclusion criteria
Exclusion criteria: 1.active bleeding caused by drugs or low platelets, and active infection that has not been controlled clinically; 2.Pregnant or lactating women; 3.Severe insufficiency of heart, kidney or liver function; 4.Drug-related or other mucosal diseases and intestinal diseases, diabetes; 5.In cases of clinical symptoms of brain function disorder or severe mental illness, one cannot understand or comply with the research protocol; 6.In cases of clinical symptoms of brain function disorder or severe mental illness, one cannot understand or comply with the research protocol; 7.Researchers believe that other reasons are not suitable for clinical trials;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Spatial transcriptomics; | — |
Countries
China
Contacts
Public ContactZhang Xi
The Second Affiliated Hospital of the Army Medical University
Outcome results
None listed