Acquired Immune Deficiency Syndrome
Conditions
Interventions
Observation group:None
Sponsors
Fujian Maternity and Child Health Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Confirmed HIV-1 infection and receipt of guideline-concordant antiretroviral therapy (ART) for >=2 years. 2.Age >=18 years at ART initiation, regardless of sex. 3.Availability of baseline laboratory data within ±14 days of ART initiation, including CD4 count, HIV-1 RNA viral load, complete blood count (CBC), and basic biochemistry. 4.At least two post-ART measurements of CD4 and HIV-1 RNA (preferably at months 6, 12, and 24).
Exclusion criteria
Exclusion criteria: 1.Virologic non-suppression at both 12 and 24 months: HIV-1 RNA not reduced to the assay lower limit of detection (250 IU/mL) at either time point. 2.Evidence at baseline of any of the following extreme laboratory abnormalities: platelet count (PLT) 400 IU/L; or eGFR <15 mL/min/1.73 m². 3.Concurrent missingness of both CD4 and HIV-1 RNA at baseline, 12 months, and 24 months (i.e., CD4 and viral load unavailable at each of these assessment windows).
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Biochemical blood routine, liver and kidney function; | — |
Primary
| Measure | Time frame |
|---|---|
| VL, CD4+; | — |
Countries
China
Contacts
Public ContactJinhua Zhang
Fujian Maternity and Child Health Hospital
Outcome results
None listed