Vascular mild cognitive impairment (VMCI)
Conditions
Interventions
Index test:The diagnostic threshold for the automatic WMH identification system: a WMH volume of 15.475 cm³.
Sponsors
Shandong Provincial Third Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Hypertensive patients aged 50 to 80 years. 2.Presence of ischemic white matter hyperintensities (WMH) on cranial magnetic resonance imaging (MRI). 3.No history of central nervous system diseases such as stroke, head trauma, encephalitis, hydrocephalus, epilepsy, Parkinson's disease, Alzheimer's disease, frontotemporal dementia, or Lewy body dementia, and no systemic diseases known to cause cognitive impairment. 4.No history of congenital mental retardation or psychiatric disorders such as anxiety or depression. 5.Not taking any medications that affect cognitive function. 6.Ability to cooperate with completing cognitive assessments [a Mini-Mental State Examination (MMSE) score of >13 for illiterate individuals, >19 for those with primary school education, and >24 for those with a junior high school education or above]. 7.Provision of signed informed consent.
Exclusion criteria
Exclusion criteria: 1.Presence of WMH from non-vascular origins, such as multiple sclerosis, sarcoidosis, cerebral radiation therapy, or leukodystrophies. 2.Presence of non-lacunar infarcts (cortical and/or subcortical) or cerebral hemorrhage. 3.Cranial MRI clearly indicating cortical or hippocampal atrophy. 4.Cognitive impairment attributable to other neurodegenerative diseases, such as Alzheimer's disease, Lewy body dementia, frontotemporal dementia, or Parkinson's disease. 5.Other cerebral pathologies, including tumors, hydrocephalus, trauma, neurosyphilis, acquired immunodeficiency syndrome (AIDS), or Creutzfeldt-Jakob disease. 6.Severe psychiatric disorders, epilepsy, alcohol or substance abuse, poisoning, or metabolic abnormalities. 7.Individuals with no abnormalities detected on cranial MRI or those unable to undergo or complete the MRI examination.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sensitivity; | — |
Countries
China
Contacts
Public ContactZhang Hui
Shandong Provincial Third Hospital
Outcome results
None listed