Fetal aneuploidy
Conditions
Interventions
Non-invasive and non-invasive fetal aneuploidy detection Observation Group (Retrospective Part):None
Non-invasive and non-invasive fetal aneuploidy detection Observation Group (Prospective part):None
Sponsors
The Second Affiliated Hospital of Kunming Medical University
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1.Since the launch of the NIPT project in 2021, pregnant women who have received clinical diagnosis and treatment at the prenatal diagnosis center of our hospital have undergone NIPT or NIPT-Plus testing. 2. Successfully conceived after receiving assisted ART from the reproductive medicine department; 3. Single fetus by B-ultrasound; 4. The gestational age for blood collection is greater than 12 weeks.
Exclusion criteria
Exclusion criteria: 1.Pregnant women who have not undergone NIPT or NIPT-Plus testing; 2. Pregnant women with other serious complications or genetic diseases; 3. Gestational age less than 12 weeks; 4. Has undergone blood transfusion or bone marrow transplantation treatment within one year; 5. Twins or fetal reduction period less than 8 weeks; 6. A confirmed family history of chromosomal inheritance; 7. There are definite chromosomal abnormalities.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fetal DNA concentration (fetal fraction);Gestational weeks;History of assisted reproductive treatment and medication; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sequencing data;Q20 ratio;Z value: Statistical count of sequencing detection; | — |
Countries
China
Contacts
Public ContactChen Ran
The Second Affiliated Hospital of Kunming Medical University
Outcome results
None listed