Chronic acute liver failure due to various causes
Conditions
Interventions
Deteriorating group:None
Sponsors
The First Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18 to 65 years old (including 18 and 65 years old); 2. Gender is not limited; 3. At admission, the patient had no serious impairment of heart, lung or kidney functions. 4. Meet the diagnostic criteria for patients with acute-on-chronic liver failure as stipulated in the "Guidelines for the Diagnosis and Treatment of Liver Failure (2018 Edition)" On the basis of chronic liver disease, a syndrome caused by various inducements, characterized by deepening acute jaundice and coagulation dysfunction as manifestations of liver failure, may be accompanied by complications including hepatic encephalopathy, ascites, electrolyte imbalance, infection, hepatorenal syndrome, hepatopulmonary syndrome, etc., as well as extrahepatic organ failure. The patient's jaundice deepened rapidly, and the total serum bilirubin was >=10×ULN or increased daily by >=17.1µmol/L. There is bleeding manifestation, PTA=1.5); 5. The research subjects were able to understand and sign the informed consent form;
Exclusion criteria
Exclusion criteria: 1.People who are highly allergic (unable to undergo plasma exchange or blood purification) or have a history of severe allergies; 2.There are patients with uncontrolled active bleeding; 3.Patients with active malignant tumor; 4.Pregnant or lactating women; 5.Patients with hyperbilirubinemia other than liver failure; 6.There are people with uncontrolled mental illness; 7.Patients who refuse to sign informed consent forms;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 13 cytokines; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood routine;Biochemical index;Hemagglutination index; | — |
Countries
China
Contacts
Public ContactYuguo Zhang
The First Hospital of Hebei Medical University
Outcome results
None listed