Pain
Conditions
Interventions
Sufentanil group:General anesthesia was induced with midazolam (2mg), parecoxib sodium (40mg), propofol (1.0-2.5 mg/kg), rocuronium (0.15-0.2 mg/kg) and sufentanil 0.5ug/kg, which were added as needed
Tegiletine group:Tygelidine 0.05mg/kg was given during induction of general anesthesia. No other opioids were used during the procedure. Other anesthesia induction, maintenance and adjuvant drugs were
Sponsors
Obstetrics and Gynecology Hospital, Fudan University
Eligibility
Sex/Gender
Female
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Age: 18 to 75 years old; 2.ASA I–III; 3. Patients who are scheduled to undergo gynecological tumor surgery under combined intravenous-inhalation general anesthesia; 4. Use the analgesic pump after the operation and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.ASA>= Grade IV; 2.BMI>35 or weight 15 u of morphine equivalent, with a frequency of > 3 days per week or > 1 week within one year); 4. Analgesic drugs have been used within 48 hours before the operation; 5. Long-term history of using non-steroidal anti-inflammatory drugs; 6. Having used drugs that may interfere with the response to analgesic drugs for more than 30 days (such as central alpha-adrenergic drugs, antiepileptic drugs, neuroleptics, antidepressants, antipsychotic drugs); 7. Corticosteroids have been used within 3 months before the operation; 8. Liver and kidney dysfunction; 9. Neurocognitive dysfunction; 10. Heart diseases (including pacemaker implantation and severe bradycardia); 11. History of allergy to anesthetic drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of adverse reactions;The effective number of PCA demands; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain assessed at rest;Pain assessed at coughing/movement;The worst pain;The first pressing time of the analgesic pump;The total number of PCA demands; | — |
Countries
China
Contacts
Public ContactDu Weijia
Obstetrics and Gynecology Hospital Affiliated to Fudan University
Outcome results
None listed