Postoperative sleep disturbance
Conditions
Interventions
Control group:Sufentanil 2µg/kg
Experimental group:Esketamine 2mg/kg
Sponsors
The First Affiliated Hospital of Dalian Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing elective unilateral total knee arthroplasty; 2. Aged >= 65 years, regardless of gender; 3. BMI 18 - 25 kg/?; 4. Patients with American Society of Anesthesiologists (ASA) physical status ? - ?; 5. Signed informed consent form.
Exclusion criteria
Exclusion criteria: 1. Presence of preoperative sleep disorders (Pittsburgh Sleep Quality Index (PSQI) score > 7 points); 2. Severe dysfunction of vital organs, complicated with ischemic heart disease or adrenal cortical insufficiency; 3. Severe neurological diseases (Parkinson's disease, Alzheimer's disease, schizophrenia, epilepsy) and long-term use of opioids, sedatives, antidepressants or anxiolytics; 4. Untreated or poorly controlled hypertension, hyperthyroidism; increased intracranial pressure, glaucoma; 5. Allergic to esketamine; 6. Difficulty in communication and inability to cooperate with the assessors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sleep Quality on the Night After Surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Surgical Data;Somnolence;Postoperative Recovery;Long-term Recovery;Analgesia;Incidence of Adverse Reactions;Perioperative Hemodynamics;Postoperative Pain; | — |
Countries
China
Contacts
Public ContactWen Chao
The First Affiliated Hospital of Dalian Medical University
Outcome results
None listed