Diabetic kidney disease
Conditions
Interventions
Control group (UACR <30 mg/g) :None
Observation group (UACR 30–300 mg/g):None
Sponsors
The First People's Hospital of Zhangjiagang City
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. All meet the 1999 WHO diagnostic and classification criteria for T2DM; 2. DKD patients all meet the diagnostic criteria of the "Expert Consensus on the Prevention and Treatment of Diabetic Kidney Disease"; that is, the glomerular filtration rate (GFR) is basically normal, and the urinary microalbumin (mAlb) excretion rate is consistently between 20–200 µg/min or 30–300 µg/24h; in the early stage, when the mAlb excretion rate is 20–70 µg/min, GFR decreases to about 130 mL/min, blood pressure rises slightly, and reduction in blood pressure can reduce mAlb excretion; 3. Patients and their families are informed and agree to participate in this study.
Exclusion criteria
Exclusion criteria: 1. Patients with type 1 diabetes, gestational diabetes, and other types of diabetes; 2. Those with acute diabetic complications; 3. Patients with malignant tumors, cardiovascular and cerebrovascular diseases, or severe infections; 4. Those with other organ dysfunctions; 5. Patients with urinary tract infections or kidney diseases other than diabetic nephropathy; 6. Pregnant and breastfeeding women; 7. Patients who have undergone dialysis or kidney transplantation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Secreted frizzled-related protein 1 (SFRP1);Growth differentiation factor 15 (GDF-15);Retinol-binding protein (RBP); | — |
Countries
China
Contacts
Public ContactWenhui Ni
The First People's Hospital of Zhangjiagang City
Outcome results
None listed