cardiac lesions with gastroesophageal reflux disease
Conditions
Interventions
Test group:Extended Mucosectomy of Lesion and Anti-Reflux procedure (ex-MLAR)
Sponsors
The First Medical Center of Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with symptoms such as regurgitation and heartburn, or those with pathological reflux indicated by the results of 24-hour esophageal pH-impedance monitoring; 2. Patients with cardiac polyps, cardiac precancerous lesions (including low-grade and high-grade intraepithelial neoplasia) or early cardiac cancer (lesions limited to the mucosa and submucosa without distant or lymph node metastasis) confirmed by endoscopic examination and biopsy pathology; 3. Patients who have signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1.The lesion invades the muscularis propria or there is distant metastasis; 2. High-resolution manometry (HRM) shows obvious primary esophageal motility disorder or high lower esophageal sphincter pressure; 3.Other severe organ diseases (such as severe cardiopulmonary insufficiency, extensive myocardial infarction, etc.); 4.Severe coagulation dysfunction; 5.Pregnant women; 6.Esophageal varices, gastrointestinal bleeding;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lesion resection rate; Results of 24-hour esophageal pH-impedance monitoring; | — |
Secondary
| Measure | Time frame |
|---|---|
| Esophageal manometry results;Gastroscopic results;GERD questionnaire;PPI discontinuation rate;Esophageal Stenosis; | — |
Countries
China
Contacts
Public ContactChai Ningli
The First Medical Center of Chinese PLA General Hospital
Outcome results
None listed