Sleep disorders after liver transplantation
Conditions
Interventions
Control group:None
DEX group:Intraoperative dexmedetomidine continuous intravenous pumping
Sponsors
The People’s Hospital of Guangxi Zhuang Autonomous Region
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients aged 18 years or older; 2. Patients who have undergone allogeneic liver transplantation surgery;
Exclusion criteria
Exclusion criteria: 1.Patients with preoperative cognitive impairment, hepatic encephalopathy, or other neurological damage; 2.Critically ill patients with multiple organ dysfunction or requiring ECMO support; 3.combined transplant patients; 4.Replant patients; 5.Contraindications for the use of dexmedetomidine (severe cardiac conduction block, severe ventricular dysfunction); 6.Patients with preoperative sleep disorders (PSQI > 7 points); 7.Long-term preoperative use of opioid medications, high doses of sleeping pills, antidepressants, and other psychiatric medications;
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Pain condition;Transcriptome;Cognitive function;Metabolomics;Anxiety state; | — |
Primary
| Measure | Time frame |
|---|---|
| Incidence of sleep disorders 3 days after surgery; | — |
Countries
China
Contacts
Public ContactLv Chengmei
The People’s Hospital of Guangxi Zhuang Autonomous Region
Outcome results
None listed