Obesity
Conditions
Interventions
Control group:Oral administration does not produce Trp-CA by Lactobacillus paracasei
Test group:Oral administration of Lactobacillus paracasei producing Trp-CA
Sponsors
Tianjin Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18–60 years, male or female; 2. Body Mass Index (BMI) between 24.0–32.0 kg/m^2 (overweight or mildly obese); 3. Recent (past 3 months) weight fluctuation not exceeding +/-2 kg; 4. Able to comprehend study content, voluntarily sign informed consent, and agree to comply with study protocol requirements; 5. No history of major illnesses or severe metabolic disorders, able to attend follow-up appointments and provide samples as scheduled.
Exclusion criteria
Exclusion criteria: 1. Individuals with diabetes, severe cardiovascular disease, abnormal liver or kidney function, or thyroid dysfunction; 2. Those who have recently (within the past 3 months) used antibiotics, probiotic supplements, glucocorticoids, weight-loss medications, or drugs affecting metabolism; 3. Individuals with a history of gastrointestinal surgery, chronic diarrhea, or other conditions affecting nutrient absorption; 4. Individuals with allergies to dairy products or probiotic products, or those with severe lactose intolerance; 5. Pregnant women, breastfeeding women, or those planning pregnancy; 6. Individuals with a history of psychiatric disorders, substance abuse, or alcoholism that may affect compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Weight;Waist circumference;Hip circumference;Fasting blood glucose;Systolic blood pressure;Diastolic blood pressure;Triglycerides;Total cholesterol;High-density lipoprotein cholesterol;Low-density lipoprotein cholesterol;Tryptophan-cholic acid;LC-19; | — |
Countries
China
Contacts
Public ContactZhongze Fang
Tianjin Medical University
Outcome results
None listed