Biological age
Conditions
Interventions
Intervention group:The product is rich in nutrients including proanthocyanidin PCC1. The final product is designed as an oral tablet, with a net content of 600mg per tablet (containing 300mg of grape
Control group:The control group will maintain their usual dietary habits and receive a placebo that does not contain the active intervention ingredients. The placebo consists only of excipients and is
Sponsors
Wuhan University
Eligibility
Sex/Gender
All
Age
30 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1.Aged 30-50 years. 2.Permanent local resident with no plans for long-distance travel within one year. 3.Willing and able to comply with the trial protocol, including completing questionnaires and undergoing procedures such as blood collection.
Exclusion criteria
Exclusion criteria: 1. Past or current illness: malignant tumors, chronic renal failure (eGFR<60), liver cirrhosis, active hepatitis, hyperthyroidism/hypothyroidism, severe cardiovascular and cerebrovascular diseases, autoimmune diseases, mental disorders 2. Those diagnosed with coagulation disorders, severe anemia, or other conditions that make blood drawing unsuitable should apply 3. Supplement health food containing main functional ingredients such as proanthocyanidins within 3 months 4. Women who are pregnant or breastfeeding 5. Special diets: vegetarian diet, ketogenic diet, extremely low-calorie diet (<800kcal/ day), or participation in other clinical trials 6. Other circumstances where the researcher deems it unsuitable to participate in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Biological age; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood routine test;Biological Age of Multi-Organ Systems;Lipid peroxidation biomarkers;Hip circumference;SASP factors;NAD+ levels;Heart rate and blood pressure;Body weight;Renal function;Height;Metabolomics;Waist circumference;Grip strength;Anthropometric measurements;Brain MRI examination;Blood glucose;Metagenomic sequencing;Liver function;Blood lipids;Blood PBMC single cell;Facial skin characteristics;Chest circumference; | — |
Countries
China
Contacts
Public ContactRong Shuang
Wuhan University
Outcome results
None listed