Obstructive Sleep Apnea-Hypopnea Syndrome
Conditions
Interventions
lowland--Population with OSAHS:Phase A: Single-night continuous positive airway pressure (CPAP) therapy. A standard fixed-pressure CPAP device is used, equipped with a heated humidifier and an oronas
highland--Population with OSAHS:Phase A: Single-night continuous positive airway pressure (CPAP) therapy. A standard fixed-pressure CPAP device is used, equipped with a heated humidifier and an orona
Sponsors
Diqing Tibetan Autonomous Prefecture People's Hospital
Eligibility
Sex/Gender
All
Age
35 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Adults aged >= 35 years, who meet the following criteria: 2.Suspected of having OSAHS (clinical manifestations are consistent with OSAHS symptoms, such as snoring, daytime sleepiness, etc., and/or preliminary screening indicates a high risk); 3.Confirmed diagnosis of OSAHS via overnight polysomnography (PSG) monitoring (apnea-hypopnea index [AHI] >= 5 events/hour), or those with no significant abnormalities on PSG (AHI < 5) may be included in the healthy control group (cohort); 4.Voluntarily participate in this study, understand the research procedures, and have signed a written informed consent form.
Exclusion criteria
Exclusion criteria: Participants who meet any of the following criteria will be excluded from the study: 1.Those unable to ensure a stable sleeping environment (e.g., frequent business trips due to work, or inconsistent nighttime sleeping locations); 2.Those with comorbid severe mental illnesses (e.g., bipolar disorder, schizophrenia, etc.) that affect compliance; 3.Those with active infectious diseases (e.g., tuberculosis, AIDS, syphilis, etc.); 4.Pregnant women; 5.Any other conditions deemed inappropriate for participation in this study by the researchers (e.g., severe physical illnesses that pose risks to intervention).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Apnea-Hypopnea Index per Hour; | — |
Secondary
| Measure | Time frame |
|---|---|
| Epworth Sleepiness Scale (ESS) Score;Pittsburgh Sleep Quality Index (PSQI);C-Reactive Protein (CRP) Level; | — |
Countries
China
Contacts
Public ContactJiaming He
Diqing Tibetan Autonomous Prefecture People's Hospital
Outcome results
None listed