Unilateral Pulmonary Edema
Conditions
Interventions
Experimental Group:Intravenous infusion of 80mg of methylprednisolone sodium succinate + 100ml of normal saline
Control Group:100ml of normal saline is administered intravenously
Sponsors
Second Affiliated Hospital of Army Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients who are scheduled to undergo minimally invasive cardiac surgery with a small incision based on their condition; 2. Age: 18-75 years old 3. American Society of Anesthesiologists (ASA) classification II - III; 4. Voluntarily take the test and sign the informed consent form; 5. Preoperative left ventricular ejection fraction (LVEF) >=45%; 6. Preoperative C-reactive protein (CRP) <=10 mg/L (excluding baseline high inflammatory state).
Exclusion criteria
Exclusion criteria: 1. Chronic obstructive pulmonary disease (COPD) GOLD grade >=2; 2. Pulmonary arterial hypertension (PASP > 50 mmHg) or right ventricular dysfunction (tricuspid annulus systolic displacement TAPSE 40 mmHg; 3. Previous history of lung diseases or lung surgeries; 4. Long-term use of glucocorticoids (> 5 mg/d equivalent dose of prednisone for more than 1 month) or immunosuppressants; 5. Poor blood glucose control in diabetes (HbA1c > 7.5%); 6. Active infections (such as pneumonia, sepsis) or autoimmune diseases (such as systemic lupus erythematosus); 7. Liver dysfunction (Child-Pugh B/C grade or ALT/AST > 3 times the upper limit of normal); 8. Renal insufficiency (eGFR < 60 mL/min/1.73m²); 9. There was an allergic reaction to methylprednisolone sodium succinate in the past; 10. Had taken other investigational drugs or participated in other clinical trials in the three months prior to being included in the study; 11. For any reason, one cannot cooperate with the research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative incidence of unilateral pulmonary edema; | — |
Secondary
| Measure | Time frame |
|---|---|
| The improvement of oxygenation function;Inflammatory regulatory effect;Respiratory mechanics and clinical outcomes; | — |
Countries
China
Contacts
Public ContactYang Guiying
Second Affiliated Hospital of Army Medical University
Outcome results
None listed