Patients Undergoing Gynecologic
Conditions
Interventions
Low dose Oliceridine group (A group):The postoperative intravenous patient-controlled analgesia (PCA) pump was prepared with oliceridine 0.3 mg/kg plus flurbiprofen axetil 150 mg and azasetron 10 mg,
Medium dose Oliceridine group (B group):The postoperative intravenous patient-controlled analgesia (PCA) pump was prepared with oliceridine 0.4 mg/kg plus flurbiprofen axetil 150 mg and azasetron 10 m
High dose Oliceridine group (C group):The postoperative intravenous patient-controlled analgesia (PCA) pump was prepared with oliceridine 0.5 mg/kg plus flurbiprofen axetil 150 mg and azasetron 10 mg,
Sponsors
Tongling People’s Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1)Aged 18-65 years; (2)ASA classification I–III; (3)18 kg/m^2 <= BMI <= 28kg/m^2 (4)Scheduled elective gynecological laparoscopic surgery; (5)Expected duration of surgery between 1 and 3 hours; (6)Written informed consent for anesthesia signed by all patients prior to surgery.
Exclusion criteria
Exclusion criteria: (1)Dysfunction of vital organs such as the heart, liver, or lungs; (2)Allergy or contraindication to any anesthetics, adjunct analgesics, rescue analgesics, antiemetics, or antibiotics used in the study; (3)Patients with chronic pain and/or those on long-term sedative or analgesic medication; (4)Central nervous system or psychiatric disorders, or inability to communicate; (5)QTc interval > 470 ms; (6)Coagulopathy; (7)Active peptic ulcer or a history of gastrointestinal bleeding; (8)Pregnant or breastfeeding women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Resting and movement VAS pain scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| Resting and movement VAS pain scores;Incidence of Postoperative Adverse Events (Nausea ,Somnolenc,Respiratory depression, Pruritus);The total and effective number of patient?controlled analgesia (PCA) button presses within 48?hours after surgery, as well as the rate of rescue analgesia, were recorded. Total and effective PCA presses within 48?hours postoperatively and the rescue analgesia rate were documented. ?? Patient?controlled analgesia (PCA):. ? total PCA presses total number of PCA button presses. ? effective PCA presses successful PCA attempts. ? rescue analgesia;Ramsay scores;Quality of Recovery-15 (QoR-15) score;The time to first postoperative flatus and the postoperative length of hospital stay were recorded for all patients.; | — |
Countries
China
Contacts
Public ContactJiang Xuehui
Tongling People’s Hospital
Outcome results
None listed