Patients with cognitive impairment related to brain injury or cerebrovascular disease
Conditions
Interventions
Intervention group:Neuromodulation, C7 nerve root resection
Sponsors
Jing'an District Central Hospital, Shanghai
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age 14-80 years, any gender; 2. Diagnosed by a neurologist with post-brain injury cognitive impairment or vascular cognitive impairment, meeting the clinical manifestations and imaging characteristics of post-brain injury cognitive impairment or vascular cognitive impairment; 3. MoCA-Basic score <24; 4. Onset time exceeding 6 months; 5. Has a stable caregiver available 24 hours a day; 6. Patient and caregiver have signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Presence of cognitive impairment caused by other non-cerebrovascular diseases or brain injuries, such as Alzheimer's disease, frontotemporal dementia, or Lewy body dementia; 2. Presence of other intracranial or extracranial lesions affecting cognitive function, such as brain tumors, severe hydrocephalus, or hypothyroidism; 3. Severe systemic diseases, such as malignant tumors, liver or kidney dysfunction, coagulopathy, or infectious diseases; 4. Patients and caregivers unable to cooperate with treatment; 5. Participation in other clinical interventional trials within the past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment - Basic Score;Activities of Daily Living;Western Aphasia Battery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ancillary Tests (EEG, sEMG, MRI, PET, Facial Expression Analysis, Eye Tracking, and Gait Analysis);Movement Disorder Society - Unified Dystonia Rating Scale;Genomics, Proteomics;Zarit Burden Interview;Neuropsychiatric Inventory;Nonverbal Cognitive Scale; | — |
Countries
China
Contacts
Public ContactWendong Xu
Jing'an District Central Hospital, Shanghai (Jing'an Branch of Huashan Hospital, Fudan University)
Outcome results
None listed