Knee Osteoarthritis
Conditions
Interventions
High-Concentration and Low-Volume Group:Drug dilution
Medium-Concentration -Volume Group:Drug dilution
Low-Concentration and High-Volume Group:Drug dilution
Sponsors
Foshan Fosun Chancheng Hospital
Eligibility
Sex/Gender
All
Age
55 Years to 80 Years
Inclusion criteria
Inclusion criteria: A total of 120 patients of both sexes, aged 55-80 yr, of American Society of Anesthesiologists physical status II or III, with body mass index of 18-27 kg/m2, scheduled for unilateral TKA under combined spinal-epidural anesthesia in our hospital from November 2025 to August 2027, were selected. Peripheral nerve block analgesia was performed under ultrasound guidance after operation.
Exclusion criteria
Exclusion criteria: 1. Pregnancy, or presence of neuropathic or neuromuscular diseases. 2. History of severe cardiovascular or cerebrovascular diseases, hepatic or renal dysfunction, cerebral stroke, or peptic ulcer disease. 3. Allergy to local anesthetics or opioids. 4. Communication disability, or history of psychological or psychiatric disorders. 5. Contraindications to regional nerve block (e.g., coagulopathy, local infection at the injection site). 6. History of alcohol abuse, or use opioid or sedative medications preoperatively.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| RVAS & MVAS; Lower Extremity Muscle Strength (Motor and Sensory Function); | — |
Countries
China
Contacts
Public ContactMeirong Wang
Foshan Fosun Chenzheng Hospital
Outcome results
None listed