Hyoxemia
Conditions
Interventions
Control group:FiO2 will be set at 100% immediately after arriving at PACU after surgery until extubation.
Trial group:FiO2 will be set at 30% immediately after arriving at PACU after surgery until extubation.
Sponsors
The Sixth Affiliated Hospital, Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 18–65 years scheduled for elective abdominal surgery in the supine position 2. ASA physical status I–III 3. Cardiac function class 1–2 4. BMI between 18 kg/m^2 and 28 kg/m^2 5. SpO2 >= 94% on room air 6. Pre-anesthesia assessment predicts no anticipated difficulty with airway management, mask ventilation, tracheal intubation, or extubation
Exclusion criteria
Exclusion criteria: 1. Recent respiratory tract infection, with preoperative chest CT showing atelectasis, pulmonary inflammation, pulmonary fibrosis, pleural effusion, etc. 2. History of thoracic surgery, or concomitant thoracic or other surgical procedures; or presence of sternum or rib fractures, chest deformity, difficulty raising both upper limbs, or scoliosis 3. Presence of gastrointestinal obstruction or high risk for reflux and aspiration, such as pregnant patients 4. History of significant organ dysfunction, such as chronic kidney disease, heart failure, hepatic insufficiency, or mobility impairment 5. Intraoperative occurrence of allergic reactions, massive hemorrhage, or suspected pulmonary embolism, pulmonary edema, or myocardial injury 6. Currently participating in other clinical studies that may interact with this study 7. Psychiatric abnormalities or cognitive impairment, leading to poor cooperation (e.g., severe auditory or visual impairment, intellectual disability, or low educational level preventing comprehension of study materials)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of hypoxemia (SpO2 < 90%) from extubation to leaving the post-anesthesia care unit (PACU); | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of pulmonary-related complications within 7 days after surgery;Arterial partial pressure of oxygen (PaO2), alveolar-arterial oxygen partial pressure difference (AaDO2), and estimated venous admixture (EVA) after tracheal extubation;Incidence of severe hypoxemia from extubation to leaving the post-anesthesia care unit (PACU);Score of lung ultrasound after extubation;Area of atelectasis shown on chest CT after extubation;Unplanned transfers to the ICU after surgery;Length of postoperative stay;Readmissions within 30 days after surgery;All deaths within 30 days after surgery;Number of adverse events related to heart, brain, kidneys, or liver 30 days after surgery; | — |
Countries
China
Contacts
Public ContactJin Sanqing
The Sixth Affiliated Hospital, Sun Yat-sen University
Outcome results
None listed