Postoperative delirium
Conditions
Interventions
Sponsors
The First Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 65 years old; 2. Intending to undergo general anesthesia with tracheal intubation for major surgery (Major surgery is defined as any operation where the estimated duration from the surgical incision to skin suturing exceeds 2 hours, and the estimated postoperative hospital stay is at least 3 days.) 3. ASA classification I - III; 4. Intending to be hospitalized for more than 72 hours after the surgery.
Exclusion criteria
Exclusion criteria: 1. Refuse to participate; 2. Patients with a history of dental caries, periodontitis or gingivitis; 3. Emergency surgery or trauma patients; 4. Mini-Mental State Examination (MMSE) score <= 23; 5. Stroke, schizophrenia, depression, Parkinson's disease, epilepsy or dementia; 6. Illiterate, with language disorder or significant hearing or vision impairment and unable to communicate; 7. Liver function at Child-Pugh grade C, severe liver dysfunction; 8. Severe renal insufficiency, requiring preoperative renal replacement therapy; 9. History of intraoperative awareness; 10. Having fallen at least once in the past 6 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of POD; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of POMS;30-day all-cause mortality rate after surgery;The pain scores (NRS scores) during rest and coughing, as well as the usage of pain relief medications, within 1 to 3 days after the surgery;AIS score 1-3 days after surgery;Incidence of postoperative nausea and vomiting (PONV) within 1 to 3 days and the usage of rescue antiemetic drugs;;QoR-15 score at 1 to 3 days after surgery;Length of hospital stay; | — |
Countries
China
Contacts
Public ContactHuayue Liu
The First Affiliated Hospital of Soochow University
Outcome results
None listed