Obstructive sleep spnea
Conditions
Interventions
Nalbuphine Group:Before digestive endoscopy, nalbuphine is intravenously infused at a dose of 0.15 mg/kg, combined with propofol infused intravenously at a dose of 1.5 mg/kg for sedation.
Sufentanil Group:Before digestive endoscopy, sufentanil is intravenously infused at a dose of 0.1 µg/kg, combined with propofol infused intravenously at a dose of 1.5 mg/kg for sedation.
Sponsors
Tianjin Nankai Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18 years or older, regardless of gender; 2.Patients scheduled for elective painless digestive endoscopy; 3.American Society of Anesthesiologists (ASA) physical status classification I-III; 4.STOP-BANG score >=3 points; 5.Good patient compliance and ability to cooperate with treatment; 6.Patients provide informed consent and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Abnormal respiratory rate or SpO2 < 95% on room air during the screening period; 2.Patients with fever or acute upper respiratory tract infection within one week; 3.Patients allergic to the study drugs or dependent on opioid drugs; 4.Patients who have participated in other interventional clinical trials within 3 months before drug administration or plan to participate in such trials during the study period 5.Other conditions deemed unsuitable for inclusion in this trial by the investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of Respiratory-Related Adverse Events :;Hypoxemia: SpO2 15 seconds;Respiratory depression: RR 30 seconds;Apnea: Absence of thoracic movement > 20 seconds; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative body movement episodes; Intraoperative propofol supplemental dose;Intraoperative manual/mask-assisted ventilation rate;Examination time; Time to full consciousness; Discharge time;Patient satisfaction evaluation for analgesia/anesthesia; | — |
Countries
China
Contacts
Public ContactYu Jianbo
Tianjin Nankai Hospital
Outcome results
None listed