adult de novo Philadelphia chromosome-positive (Ph+) B/myeloid mixed phenotype acute leukemia
Conditions
Interventions
The study group:VOP regimen
Sponsors
The First Affiliated Hospital, College of Medicine, Zhejiang University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Before enrollment, a diagnosis of newly diagnosed Ph+ B-myeloid mixed phenotype acute leukemia.The diagnostic criteria refer to the 2022 WHO classification; 2.Age >= 18 years,= 3months; 5. No organ dysfunction that would restrict the use of this protocol during the screening period; 6.Understand the study and sign the informed consent form; 7. Men, women of childbearing age (postmenopausal women must have been menopausal for at least 12 months to be considered infertile), and their partners voluntarily adopt contraceptive measures deemed effective by the researchers during the treatment period and at least 12 months after the last use of the study drug.
Exclusion criteria
Exclusion criteria: 1. Patients with known to involve the central nervous system (CNS) or have extramedullary lesions; 2. History of myocardial infarction within 12 months, or clinically manifest heart diseases (including but not limited to unstable angina pectoris, congestive heart failure, uncontrolled hypertension, and uncontrolled arrhythmia, etc.); LVEF 1.5 ULN (upper limit of normal); ALT or AST > 2.5 ULN; serum creatinine > 1.5 ULN;triglyceride >3 ULN; 6. Known HIV infection; 7.Conditions affecting the use of the study drug as assessed by the investigator; 8. Inability to understand or comply with the study protocol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complete Remission Rate;3 courses of complete molecular response; | — |
Secondary
| Measure | Time frame |
|---|---|
| Advent Event;Overall survival;Event free survival;Minimal Residual disease;Relapse free survival; | — |
Countries
China
Contacts
Public ContactJie Jin
The First Affiliated Hospital, College of Medicine, Zhejiang University
Outcome results
None listed