Postoperative pulmonary complications, defined as the occurrence of any pre-selected complication within the first 5 days postoperatively. Pre-selected complications include new atelectasis
Conditions
Interventions
high FiO2 group:Intraoperative inhalation uses 80% inspired oxygen concentration
low FiO2 group:Intraoperative inhalation uses 40% inspired oxygen concentration
Sponsors
Fifth Affiliated Hospital, Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age > 18 years old, ASA grade 2-3; 2.Laparoscopic surgery under general anesthesia is planned, and the expected mechanical ventilation time is greater than or equal to 2 hours; 3.BMI>=25; 4.Family members and research subjects can cooperate with relevant trials and voluntarily sign the informed consent form;
Exclusion criteria
Exclusion criteria: 1.Previous lung surgery; 2.Invasive mechanical ventilation for more than 30 minutes in the last 30 days prior to surgery; 3.Combined with lung diseases such as asthma and chronic obstructive pulmonary disease, or preoperative diseases such as acute lung infection, intrathoracic disease, mediastinal tumor, etc; 4.Severe heart, kidney, and other organ dysfunction (acute coronary syndrome, decompensated heart failure, severe arrhythmias, severe valvular disease, preoperative dialysis, etc.); 5.Combined mental system diseases; 6.Coagulation dysfunction, hematological system disease, or malignant tumors in other parts; 7.Intraoperative prone or lateral position is required during surgery; 8.Currently participating in another interventional study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oxygenation index before and after surgery;Early postoperative pulmonary complications; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative wound infection or wound healing disorder;Admitted to the intensive care unit or readmitted to the hospital within 30 days after surgery;Postoperative nausea and vomiting;Intraoperative adverse events: hypoxemia (SpO? = 92% for >1 minute), hypotension (systolic blood pressure 2 minutes), bradycardia (heart rate 20%); | — |
Countries
China
Contacts
Public ContactDezhao Liu
Fifth Affiliated Hospital, Sun Yat-Sen University
Outcome results
None listed