Obesity
Conditions
Interventions
FiO2 40% group (L group):After intubation during the perioperative period, mechanical ventilation was used to inhale an oxygen concentration of 40% until the tracheal tube was removed.
FiO2 60% group (M group):After intubation during the perioperative period, mechanical ventilation was used to inhale an oxygen concentration of 60% until the tracheal tube was removed.
FiO2 80% group (H group):After intubation during the perioperative period, mechanical ventilation was used to inhale an oxygen concentration of 80% until the tracheal tube was removed.
Sponsors
The First Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Age range: 18 to 45 years old; 2. ASA (American Society of Anesthesiologists Classification) grades II-III; 3. Body mass index (BMI) 35-45kg/m^2; 4. Patients undergoing elective laparoscopic sleeve gastrectomy; 5. No history of drug allergies or abnormal anesthesia; 6. Preoperative blood oxygen saturation ?=94%; 7. Plan to remove the tracheal tube in the operating room.
Exclusion criteria
Exclusion criteria: 1.Patients with a history of ALI/ARDS within 3 months; 2. Patients with blood oxygen saturation<94% without oxygen inhalation before surgery; 3. Severe pulmonary dysfunction and severe chronic obstructive pulmonary disease patient; 4.Patients with severe cardiac dysfunction (preoperative LVEF<30% or NYHA grade IV); 5. Severe liver dysfunction (Child Pugh C grade); 6. Patients with severe renal dysfunction (undergoing dialysis before surgery); 7. Patients who plan to be transferred to the ICU after surgery; 8. Refusal to join clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oxygenation index 30 minutes after extubation following surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Arterial blood gas measurements at 5 min after room entry, 30 min after extubation, and 24 h postoperatively;Percentage area of Central Ventilation (CoV), Dependent Stable Zone (DSS), and Non-dependent Stable Zone (NSS) during EIT monitoring at 5 min after room entry and 30 min after extubation;Hemodynamic parameters: Heart rate (HR), Mean arterial pressure (MAP), Systolic blood pressure (SBP);The total intraoperative doses of neuromuscular blocking agents, opioids, and cyclopropofol were recorded.; | — |
Countries
China
Contacts
Public ContactGuo Qiongmei
The First Hospital of Hebei Medical University
Outcome results
None listed