Occult lymph node metastasis in lung cancer
Conditions
Interventions
Lymph node N0:None
Lymph node N1+2:None
Sponsors
Army Medical Center of PLA
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1.According to the international TNM staging criteria (8th edition), the patients are those with lung adenocarcinoma who have a preoperative clinical stage of T1-T2aN0M0. Among them, for patients with T1a stage, the maximum diameter of the tumor is less than 1 cm; for T1b stage, the maximum diameter of the tumor is 1-2 cm; for T1c stage, the maximum diameter of the tumor is 2-3 cm; for T2a stage, the maximum diameter of the tumor is 3-4 cm. Additionally, it includes patients with a tumor whose maximum diameter is <=4 cm and invades the visceral pleura. 2.The CT imaging reports describe the nodules as solid or subsolid nodules, and the mediastinal and hilar lymph nodes are not described as enlarged or suspected of metastasis (preoperative clinical cN0). 3.All patients underwent anatomical pulmonary resection combined with systematic lymph node dissection or sampling. The surgical procedures include thoracoscopic or robotic lobectomy and segmentectomy, and the surgical records are complete, enabling accurate acquisition of the tumor specimens and the situation of lymph node dissection. The pathological type is invasive adenocarcinoma. 4.The patients were aged between 18 and 90 years old. 5.All patients underwent chest CT examination before surgery, and the image quality can meet the requirements for measuring the tumor location and evaluating relevant indicators.
Exclusion criteria
Exclusion criteria: 1.Patients who had received neoadjuvant chemotherapy, radiotherapy or targeted therapy before surgery, which could affect the detection rate of lymph node metastasis. 2.Patients who did not undergo systematic lymph node dissection or sampling during the operation. 3.Patients with a clinical stage of T2b - T4 (the maximum diameter of the tumor > 4 cm), or lymph node stage N3, or stage M1 (with distant metastasis). 4.Patients whose pulmonary nodules were described as ground-glass nodules or mixed ground-glass nodules in the preoperative chest CT. 5.Patients with postoperative pathology clearly diagnosed as adenocarcinoma in situ or minimally invasive adenocarcinoma. 6.Patients with a history of other malignant tumors (except for multiple primary carcinomas of non-small cell lung cancer). 7.Patients whose chest CT images had severe artifacts or were missing, making it impossible to accurately measure the tumor location and related indicators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measurement indicators of tumor location; | — |
Secondary
| Measure | Time frame |
|---|---|
| The mean value of CT (Computed Tomography);The maximum diameter of the tumor; | — |
Countries
China
Contacts
Public ContactDeng Bo
Army Medical Center of PLA
Outcome results
None listed