Co infection of carbapenem resistant Klebsiella pneumoniae and Acinetobacter baumannii in immunosuppressed lung transplantation
Conditions
Interventions
Coexistent infection group:None
CRKP infection group:None
CRAB infection group:None
Sponsors
Wuxi People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Lung transplant recipients aged 18 years or older; 2. Evidence of lower respiratory tract infection, with at least two of the following: abnormal body temperature (greater than 38.5°C or less than 36.5°C), or increased purulent respiratory secretions or other infection symptoms, or abnormal white blood cell count (greater than 12×10^9/L or less than 4×10^9/L), significantly elevated CRP, or pulmonary imaging (chest CT or chest X-ray) suggesting new inflammatory lesions or progressive infiltrates in the lungs; 3. Those who meet the above criteria and require bronchoscopy for bronchoalveolar lavage examination.
Exclusion criteria
Exclusion criteria: 1. Unstable vital signs; 2.Consciousness disorders, cerebrovascular accidents, stroke; 3.Septic shock/ARDS; 4. Acute coronary syndrome; 5. Recently, there has been severe hemoptysis; 6. Severe bleeding tendency; 7.Smoking; 8.Severe impairment of lung function, accompanied by severe hypoxemia, and inability to tolerate bronchoscopy examination.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Drug sensitivity test; | — |
Secondary
| Measure | Time frame |
|---|---|
| Microbial diversity of the microbiome; | — |
Countries
China
Contacts
Public ContactWang Hongmei
Wuxi People's Hospital
Outcome results
None listed