Treatment-resistant schizophrenia
Conditions
Interventions
Exosome Treatment group:Extracellular vesicles derived from mesenchymal stem cells
Sponsors
The Third People's Hospital of Foshan (Foshan Mental Health Center)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Meet the diagnostic criteria for schizophrenia according to either the "ICD-10" or the "DSM-5"; 2.Fulfill the definition of treatment-resistant schizophrenia (i.e., lack of satisfactory response to adequate dose and duration treatment with at least two different classes of antipsychotic drugs); 3.Aged 18 to 60 years, regardless of gender; 4.Have provided signed informed consent and voluntarily agree to participate in the study.
Exclusion criteria
Exclusion criteria: 1.Presence of severe somatic diseases (e.g., hepatic or renal failure); 2.Significant history of substance dependence or abuse; 3.Pregnancy or lactation; 4.Contraindications to MRI; 5.Previous treatment with stem cell or exosome therapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Positive and Negative Syndrome Scale Score ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Bech-Rafaelsdn Mania Rating Scale Score ;Magnetic Resonance Imaging;Changes in Inflammatory Factor Levels;Montreal Cognitive Assessment Score ;Adverse Event;Hamilton Depression Scale Score ;Changes in Immune Function Parameters;Hamilton Anxiety Scale Score ; | — |
Countries
China
Contacts
Public ContactRunyi Li
The Third People's Hospital of Foshan (Foshan Mental Health Center)
Outcome results
None listed