PCOS
Conditions
Interventions
Study group:D-chiro-inositol was administered orally at a dose of 500 mg, twice daily before meals, starting from day 2-3 of the menstrual cycle preceding ovarian stimulation and continuing until the
Control group:Metformin is initiated at a dose of 500 mg twice daily (bid), taken with meals, starting on day 2-3 of the menstrual cycle, one menstrual period prior to ovarian stimulation, and continu
Sponsors
Sichuan Provincial Women and Children's Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: PCOS patients aged 20-40 years, with comorbid metabolic syndrome (characterized by at least one of the following: obesity, hyperglycemia, dyslipidemia, hyperuricemia, fatty liver disease, or hyperinsulinemia), underwent ovarian stimulation using a gonadotropin-releasing hormone antagonist protocol, followed by IVF-ET.
Exclusion criteria
Exclusion criteria: 1. Preimplantation genetic testing (PGT) cycle; 2. Factors affecting embryo implantation, such as submucosal uterine fibroids, intramural fibroids, adenomyosis, intrauterine adhesions, uterine malformations, thin endometrium, etc.; 3. Presence of severe chronic diseases of the cardiovascular, respiratory, or digestive systems, or severe endocrine or immune diseases such as diabetes mellitus or systemic lupus erythematosus; 4. Participation in other drug or device clinical trials within 3 months prior to treatment, with the use of investigational drugs or devices; 5. Allergy to inositol or metformin; 6. Body mass index (BMI) = 28; 7. Other medical conditions deemed by the investigator as potentially interfering with the judgment of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| clinical pregnancy rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Embryo implantation rate;Biochemical pregnancy rate; | — |
Countries
China
Contacts
Public ContactGong Yan
Sichuan Provincial Women’s and Children’s Hospital
Outcome results
None listed