Oral potentially malignant disorders (with or without epithelial dysplasia) including oral leukoplakia, oral erythroplakia, oral lichen planus, oral submucosal fibrosis
Conditions
Interventions
Index test:AI-Driven Multi-Gene Methylation Risk Assessment Model for Oral Mucosal Carcinogenesis
Sponsors
Hospital of Stomatology, Wuhan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients clinically diagnosed with oral leukoplakia, oral erythroplakia, oral lichen planus, oral submucous fibrosis, or other potentially malignant oral disorders, as well as patients with suspected oral cancer, from whom extra normal oral mucosa can be obtained during wisdom tooth extraction or reconstructive surgery; 2. Willing to undergo histopathological examination, with pathology showing any of the five categories: normal oral mucosa, simple epithelial hyperplasia, mild epithelial dysplasia, moderate-to-severe epithelial dysplasia, or oral squamous cell carcinoma; 3. Understand the project and provide informed consent by signing the consent form.
Exclusion criteria
Exclusion criteria: 1.Patients with coagulation disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Area under receiver operating characteristic curve (AUC);Sensitivity;Specificity; | — |
Secondary
| Measure | Time frame |
|---|---|
| The number of detected genes for constructing the model; | — |
Countries
China
Contacts
Public ContactLu Rui
Hospital of Stomatology, Wuhan University
Outcome results
None listed