Major Depressive Disorder
Conditions
Interventions
The vitamin D sufficiency with mild-to-moderate depression group:None
The vitamin D sufficiency with severe depression group:None
Vitamin D-Sufficient/Deficient, Mild-to-Moderate Depression Group:None
Vitamin D deficiency mild to moderate depression group:None
Sponsors
Affiliated Hospital of GuiZhou Medical University
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 12–18 years who meet the DSM-5 criteria for a depressive episode; 2. Right-handed; 3. With more than >6 years of formal education; 4. A baseline score >= 8 on the 24-item Hamilton Depression Rating Scale (HAMD-24); 5. Provision of voluntary informed consent; 6. Serum 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] level < 30 ng/L, as defined by the assessment criteria for vitamin D deficiency established by the Endocrine Society.
Exclusion criteria
Exclusion criteria: 1. History of psychiatric or manic disorders; 2. Inability to definitively attribute the depressive symptoms to major depressive disorder rather than other conditions (e.g., substance abuse, or relevant medical conditions including epilepsy and a history of abnormal EEG); 3. Comorbid severe or unstable medical illnesses; 4. History of neurological disorders or traumatic brain injury; 5. Any other condition deemed by the investigator as inappropriate for participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1,25-Dihydroxyvitamin D;Disease assessment (evaluated using the 24-item Hamilton Depression Rating Scale and the Self-Rating Depression Scale);Cognitive function changes;Changes in the degree of anhedonia; | — |
Secondary
| Measure | Time frame |
|---|---|
| Brain functional changes; | — |
Countries
China
Contacts
Public ContactWang Yiming
Affiliated Hospital of GuiZhou Medical University
Outcome results
None listed